Shaping the Future of Diagnostics: Delta Diagnostics’ Integrated Optics

Shaping the Future of Diagnostics: Delta Diagnostics’ Integrated Optics

In our journey through Delta Diagnostics, we’ve seen how integrated photonics is revolutionizing life science research and drug discovery. But the story doesn’t end there. The same groundbreaking technology that accelerates research is poised to reshape in vitro diagnostics (IVD). In this episode, we’ll explore how integrated optics offers unique advantages for multiplexed IVD tests, providing accurate and rapid detection of multiple biomarkers, all in real time.

Integrated Optics: Advancing IVD

Integrated optics, a cornerstone of Delta Diagnostics’ innovation, offers a promising avenue for revolutionizing in vitro diagnostics. The ability to quantitatively detect multiple biomarkers simultaneously in small samples is a game-changer.

Real-Time Detection: A Leap Forward

Traditional diagnostic methods often rely on time-consuming labeling steps and endpoint measurements, delaying results. Integrated optics, being label-free, allows for real-time monitoring of biomarker binding. This means that tests can provide results within minutes, significantly reducing turnaround time and enhancing patient care.

The Power of Multiplexing

One of the most compelling advantages of integrated optics in IVD is its ability to simultaneously detect multiple biomarkers. Instead of relying on single-biomarker tests, which can miss important information, panels of biomarkers can be assessed in one go. This comprehensive approach offers several key benefits:

Enhanced Accuracy: Panels of biomarkers can provide a more holistic view of a patient’s condition, reducing the risk of false positives or negatives. This enhances the reliability of diagnostic results.

Disease Profiling: Multiple biomarkers can reveal nuanced information about disease states, allowing for more precise diagnoses and treatment decisions.

Early Detection: The ability to detect multiple biomarkers at once increases the likelihood of catching diseases at earlier stages when interventions can be more effective.

Applications in Healthcare

The applications of integrated optics in IVD are vast. It can be used for a wide range of tests, from detecting infectious diseases and monitoring chronic conditions to screening for cancer and assessing organ function. The speed, accuracy, and multiplexing capabilities of this technology make it a promising tool in modern healthcare.

Conclusion

Delta Diagnostics’ integrated optics technology is poised to revolutionize in vitro diagnostics. Its ability to quantitatively detect multiple biomarkers in real-time, without the need for labeling, sets the stage for faster, more accurate, and comprehensive diagnostic tests. As we continue to explore the limitless possibilities of this groundbreaking technology, we can anticipate a future where diagnostics are not only more reliable but also more accessible, ultimately improving patient outcomes and the practice of medicine as a whole. Stay tuned for more exciting developments on this incredible journey of innovation!

Shedding Light on Integrated Photonic Biosensors: The Magic of Waveguides

Shedding Light on Integrated Photonic Biosensors: The Magic of Waveguides

As we journey deeper into the world of Delta Diagnostics’ groundbreaking technology, we find ourselves at the heart of integrated photonic biosensors. In this episode, we’ll unveil the inner workings of these remarkable sensors, starting with the magic of waveguides. These tiny optical pathways, akin to optical fibers on a chip, guide light through bends and across the optical landscape, forming the foundation of biosensors with unmatched precision.

The Wonders of Waveguides

Waveguides play a crucial role in integrated photonic biosensors, but often do not receive the recognition they deserve. Think of them as miniature optical fibers but confined to a tiny chip’s surface. They possess the remarkable ability to guide light, even as it twists and turns along their path. This unique feature allows them to transport light across the optical chip, where it meets its destiny as a sensor.

The Birth of Sensors

Waveguides don’t just carry light; they can also be transformed into sensors. Here’s where the magic truly begins. At the surface of the waveguide, an enchanting phenomenon occurs—the evanescent field emerges. This field extends just beyond the waveguide’s surface into the surrounding medium, whether it’s a biological sample or something else.

The Dance of Biomolecules and Light

Imagine biomolecules in your sample, floating through the evanescent field. These molecules can bind to specific receptors that have been immobilized on the waveguide’s surface. When the right biomolecules bind to these receptors, they create a local change in the refractive index—affecting the speed at which light travels along the waveguide.

Light Speed and Biomolecule Concentration

Now comes the fascinating part: this change in refractive index affects the speed at which light travels in the sensor. Delta Diagnostics’ instruments are equipped with the remarkable capability to detect even the slightest variations in this light speed. It’s like catching the subtlest ripple in a pond.

Determining Biomolecule Concentrations

By precisely measuring these minute changes in light speed, Delta Diagnostics’ instruments can determine the concentration of biomolecules in your sample. This level of sensitivity allows for accurate, quantitative detection, making it invaluable in various applications, from medical diagnostics to environmental monitoring.

Coming Up Next…

In our next episode, we’ll delve into the different waveguide configurations used by Delta Diagnostics’ instruments to determine these light speed differences. Get ready for a deeper dive into the technological marvels that make integrated photonic biosensors a game-changer in the world of biosensing and diagnostics. Stay tuned for more enlightening insights and innovations!

Waveguide Magic: Unraveling Biosensors Through Phase Differences

Waveguide Magic: Unraveling Biosensors Through Phase Differences

The exploration of integrated photonic biosensors unfolds a world where light manipulates the detection of biomolecules with exceptional precision. This journey delves into the heart of waveguide configurations such as ring resonators and Mach-Zehnder interferometers, showcasing their critical role in biosensing technology. By detecting phase differences induced by changes in the refractive index, these devices open a new chapter in the precise identification of biomolecules.

The Role of Waveguide Sensors

Waveguides transform into sensors with remarkable sensitivity through configurations like ring resonators and Mach-Zehnder interferometers. These structures excel in their respective domains by manipulating light in unique ways. The interaction of biomolecules with receptors on the waveguide surface alters the local refractive index, subsequently affecting light’s speed. This intricate dance between biomolecules and light is pivotal in sensing technology, where the minutest changes are captured with finespan precision.

Interpreting Phase Differences

The phenomenon of phase differences stands at the core of waveguide biosensors’ functionality. Ring resonators employ circular waveguides to create resonant conditions for specific light wavelengths. Any alteration in the refractive index, such as those caused by biomolecule binding events, shifts the resonant condition, detectable through changes in light intensity. Similarly, Mach-Zehnder interferometers split light into two paths, with any phase changes in the sample path causing interference patterns upon recombination. These patterns, or variations in light intensity, are indicative of biomolecule interactions.

A Symphony of Light Intensity

The ultimate detection in both ring resonators and Mach-Zehnder interferometers boils down to light intensity variations at the output. These variations, stemming from biomolecule-induced phase differences, are precisely detected by instruments designed for this purpose. The quantitative measurement of biomolecules is achieved with unmatched sensitivity, underlining the efficacy of waveguide-based sensors in biosensing.

Conclusion

Waveguide-based sensors, through their innovative use of phase differences, have revolutionized the field of biosensing. By translating changes in the refractive index into detectable light intensity variations, they offer a powerful tool for the accurate detection of biomolecules. As we continue to unravel the potential of these devices, their impact on diagnostics and biosensing technology promises to be profound. The future episodes will delve deeper into the specifics of Delta Diagnostics’ instruments and their role in advancing biosensor capabilities, marking a significant milestone in the journey towards groundbreaking diagnostics.

Supply Chain & Purchasing Officer

Job Vacancy: Supply Chain and Purchasing Officer – Medior level

Company: Delta Diagnostics

Location: Rotterdam, The Netherlands

Employment Type: 0.4-0.6 FTE

Experience: > 5 years

About Delta Diagnostics:

Delta Diagnostics is a leading developer of cutting-edge life-science research instruments based on photonic integrated circuit technology that was invented at TNO – The Netherlands Organization for Applied Scientific Research. With a strong commitment to advancing scientific knowledge and vastly accelerating the development of new drugs and diagnostic tests, Delta Diagnostics is at the forefront of innovation, developing state-of-the-art label-free biosensors that empower researchers and healthcare professionals worldwide. We aim to deliver highly reliable, efficient, and user-friendly instruments that enable researchers to unravel the complexities of biological samples and accelerate scientific breakthroughs.

We are dedicated to creating instruments that not only provide accurate and precise results but also streamline workflows, saving researchers valuable time and resources. Our ultimate goal is to contribute to the improvement of global healthcare by facilitating the development of innovative diagnostic tools and accelerating the development of new drugs.

Join us at Delta Diagnostics as we embark on this exciting journey of discovery and innovation, where your expertise and passion can make a significant impact on scientific advancements and patient care. Together, let’s shape the future of life-science research and diagnostics.

Job Description:

We are seeking a highly motivated and detail-oriented Supply Chain and Purchasing Officer to join our dynamic team. The Supply Chain and Purchasing Officer will play a critical role in managing and optimizing our supply chain processes and purchasing activities to ensure the seamless flow of materials and products necessary for the success of our operations. This position offers an exciting opportunity for an individual with strong organizational skills and a background in supply chain management and purchasing within the life science industry.

Key Responsibilities:

  • Develop and implement supply chain strategies to optimize efficiency, minimize costs, and ensure timely delivery of materials and products.
  • Coordinate with suppliers to negotiate contracts, monitor performance, and resolve any issues or discrepancies.
  • Manage inventory levels to maintain adequate stock levels while minimizing excess inventory and carrying costs.
  • Oversee the purchasing process, including sourcing suppliers, obtaining quotes, issuing purchase orders, and tracking deliveries.
  • Collaborate closely with cross-functional teams, including product development, laboratory, business development and SHEQ, to align supply chain activities with business objectives.

Requirements

  • Master’s degree in supply chain management, business administration, or a related field. Advanced degree or professional certification (e.g., APICS, CSCP) is a plus.
  • Minimum of 5 years of experience in supply chain management and purchasing, preferably within the life science or pharmaceutical industry.
  • Strong understanding of supply chain principles, practices, and methodologies.
  • Proven ability to manage multiple projects simultaneously and meet tight deadlines.
  • Excellent analytical skills with the ability to interpret data, identify trends, and make data-driven decisions.
  • Effective communication and interpersonal skills with the ability to collaborate cross-functionally and build strong relationships with internal and external stakeholders.
  • Proficiency in using supply chain management software and tools (e.g., ERP systems, inventory management software).
  • Demonstrated problem-solving abilities and a proactive approach to identifying and resolving issues.
  • Flexibility to adapt to changing priorities and business needs in a fast-paced startup environment.

Our offer:

We offer competitive compensation, a stimulating scale-up environment, opportunities for professional growth and development and as a plus (if you stay for the duration) a generous cash bonus on exit scheme. If you are a highly motivated Supply Chain and Purchasing proffesional with a passion for cutting-edge technology and are excited about the opportunity to contribute to the field of label-free biosensing instruments, we would love to hear from you. Please submit your resume and cover letter to careers@deltadiagnostics.nl .

Delta Diagnostics is an equal opportunity employer committed to diversity and inclusion in the workplace. We encourage individuals from underrepresented groups to apply.

Unsolicited services or offers from recruitment agencies or intermediaries will not be responded to.

Enhancing Early Kinetic Screening for Optimal Drug Candidate Selection Using Integrated Photonics

Enhancing Early Kinetic Screening for Optimal Drug Candidate Selection Using Integrated Photonics

In biomedical innovation, Delta Diagnostics stands at the forefront with its pioneering use of integrated photonics in high-plex biosensing. This article provides an in-depth exploration of how this cutting-edge technology is set to transform the field of drug discovery. Delta Diagnostics’ approach facilitates high-plex detection and introduces a paradigm shift in high throughput screening, thereby revolutionizing the initial stages of drug development. A critical focus of our discussion is the role of early kinetic screening in mitigating the risk of prematurely discarding promising drug candidates.

High Throughput Screening: A Shift in Drug Discovery

At the core of Delta Diagnostics’ strategy lies the application of integrated photonics, which enables the coexistence of multiple biosensors within a compact chip. This integration is a significant stride forward for high-plex detection and advancing high throughput screening to previously unattainable levels.

Drug discovery is inherently complex and time-intensive. Historically, early stages predominantly involved affinity measurements, primarily carried out through ELISA tests. Although these tests yield valuable data, they provide only a partial view. A critical element often overlooked is the kinetics of the interactions between potential drug candidates and their targets.

(Early) Kinetic Screening

The kinetic understanding of molecular interactions is crucial in drug discovery. It encompasses more than the mere strength of a compound’s binding to its target (affinity); it also includes the speed and reversibility of this binding. Kinetic screening thus offers pivotal insights into these dynamics, granting a more nuanced comprehension of a compound’s pharmacological profile.

Conventionally, kinetic screening was relegated to the later phases of drug discovery due to technological constraints. However, Delta Diagnostics’ innovative use of integrated photonics makes early kinetic screening possible and highly efficient. The implications of this advancement are profound:

  1. Reducing Attrition: Many potential drug candidates are excluded in the discovery process because they exhibit promising affinity but fail when their kinetic properties are evaluated in subsequent stages. Early kinetic screening identifies these issues sooner, curtailing the likelihood of costly late-stage disappointments.
  2. Enhanced Candidate Selection: By incorporating kinetic considerations early in the drug discovery process, researchers can select candidates with a strong binding affinity and favourable kinetic profiles, thereby improving the chances of successful drug development.
  3. Conservation of Time and Resources: Early kinetic screening streamlines the drug discovery pathway. Researchers can swiftly pinpoint compounds with desirable kinetic properties, allowing them to allocate resources more effectively towards the most promising candidates.

Integrated photonics is on the verge of revolutionizing drug discovery by facilitating early kinetic screening. This advancement in assessing molecular interactions promises significant improvements in selecting the most suitable drug candidates, thereby reducing attrition rates. As we progress, the field anticipates more efficient and fruitful drug development processes, ultimately leading to advanced treatments and therapies for many diseases. Delta Diagnostics remains at the helm of these exciting advancements in life sciences, continually expanding the horizons of what is achievable. Stay tuned for further groundbreaking developments in this domain.