Enhancing Early Kinetic Screening for Optimal Drug Candidate Selection Using Integrated Photonics

Enhancing Early Kinetic Screening for Optimal Drug Candidate Selection Using Integrated Photonics

In biomedical innovation, Delta Diagnostics stands at the forefront with its pioneering use of integrated photonics in high-plex biosensing. This article provides an in-depth exploration of how this cutting-edge technology is set to transform the field of drug discovery. Delta Diagnostics’ approach facilitates high-plex detection and introduces a paradigm shift in high throughput screening, thereby revolutionizing the initial stages of drug development. A critical focus of our discussion is the role of early kinetic screening in mitigating the risk of prematurely discarding promising drug candidates.

High Throughput Screening: A Shift in Drug Discovery

At the core of Delta Diagnostics’ strategy lies the application of integrated photonics, which enables the coexistence of multiple biosensors within a compact chip. This integration is a significant stride forward for high-plex detection and advancing high throughput screening to previously unattainable levels.

Drug discovery is inherently complex and time-intensive. Historically, early stages predominantly involved affinity measurements, primarily carried out through ELISA tests. Although these tests yield valuable data, they provide only a partial view. A critical element often overlooked is the kinetics of the interactions between potential drug candidates and their targets.

(Early) Kinetic Screening

The kinetic understanding of molecular interactions is crucial in drug discovery. It encompasses more than the mere strength of a compound’s binding to its target (affinity); it also includes the speed and reversibility of this binding. Kinetic screening thus offers pivotal insights into these dynamics, granting a more nuanced comprehension of a compound’s pharmacological profile.

Conventionally, kinetic screening was relegated to the later phases of drug discovery due to technological constraints. However, Delta Diagnostics’ innovative use of integrated photonics makes early kinetic screening possible and highly efficient. The implications of this advancement are profound:

  1. Reducing Attrition: Many potential drug candidates are excluded in the discovery process because they exhibit promising affinity but fail when their kinetic properties are evaluated in subsequent stages. Early kinetic screening identifies these issues sooner, curtailing the likelihood of costly late-stage disappointments.
  2. Enhanced Candidate Selection: By incorporating kinetic considerations early in the drug discovery process, researchers can select candidates with a strong binding affinity and favourable kinetic profiles, thereby improving the chances of successful drug development.
  3. Conservation of Time and Resources: Early kinetic screening streamlines the drug discovery pathway. Researchers can swiftly pinpoint compounds with desirable kinetic properties, allowing them to allocate resources more effectively towards the most promising candidates.

Integrated photonics is on the verge of revolutionizing drug discovery by facilitating early kinetic screening. This advancement in assessing molecular interactions promises significant improvements in selecting the most suitable drug candidates, thereby reducing attrition rates. As we progress, the field anticipates more efficient and fruitful drug development processes, ultimately leading to advanced treatments and therapies for many diseases. Delta Diagnostics remains at the helm of these exciting advancements in life sciences, continually expanding the horizons of what is achievable. Stay tuned for further groundbreaking developments in this domain.

Integrated Photonics in Biosensing: Exploring the Advantages

Integrated Photonics in Biosensing: Exploring the Advantages

Biosensing is crucial in propelling advancements in life science research and drug discovery. At the heart of these advancements lies the integration of photonics in high-plex biosensing—a technological revolution redefining the boundaries of diagnostics and research. Integrated photonics distinguishes itself by its capability to detect multiple interactions within a single sample simultaneously. This article delves into how integrated photonics transforms biosensing, highlighting its pivotal role in efficiently determining binding kinetics for various antibodies.

The Evolution of Integrated Photonics in Biosensing

In recent years, biosensing has significantly transformed, primarily attributed to the integration of photonics. This innovative approach has enabled the development of compact, multi-functional chips capable of hosting an array of biosensors. The essence of this technology lies in harnessing the unique properties of light, thereby facilitating high-plex biosensing capable of concurrently detecting numerous interactions. Such advancements are particularly noteworthy in the context of rapid and precise processes required in life science research and diagnostics.

A hallmark of integrated photonics in biosensing is exemplified by sophisticated instruments capable of analyzing a vast array of interactions within a single sample. These instruments represent a quantum leap in the field, enhancing the efficiency and accuracy of life science research and diagnostic procedures.

An Example: Biosensing for Antibodies

In the sphere of diagnostics, the selection of the most effective antibody is a critical juncture. Traditionally, this process has been slow and resource-heavy. However, the advent of integrated photonics in biosensing has revolutionized this process. This technology significantly accelerates and refines the antibody selection process by offering a more efficient, less resource-intensive approach.

Antibodies are central to the efficacy of diagnostic tests and are tasked with identifying and binding to biomarkers. Understanding the binding kinetics of antibodies—how swiftly and robustly they adhere to their targets—is crucial in determining the effectiveness of diagnostic tests. Integrated photonics enables the simultaneous evaluation of multiple antibodies, streamlining the process of selecting an antibody with optimal binding characteristics.

The implications of high-plex biosensing technology transcend antibody selection. This technology empowers researchers to investigate complex biological interactions thoroughly, unlocking previously inaccessible insights. Its applications span a vast array, from drug discovery to biomarker identification, opening new frontiers in life science research.

Integrated Photonics: Catalyzing Advanced Research & Diagnostics

Integrated photonics is not just an incremental improvement in biosensing; it represents a paradigm shift. Facilitating the analysis of multiple interactions within a single sample significantly enhances the efficiency and speed of both diagnostics and broader research initiatives. This technology stands as a cornerstone in the ongoing evolution of biosensing, continually driving innovation and redefining what is possible in the field of life sciences.

Integrating photonics into biosensing marks a new time in diagnostics and life science research. This advancement is instrumental in advancing high-plex biosensing, offering unprecedented efficiency and precision in various aspects of research and diagnostics. The future of biosensing, closely intertwined with the developments in integrated photonics, promises a continued trajectory of groundbreaking innovations. As we move forward, integrated photonics for biosensing will remain a pivotal force in shaping the landscape of life sciences, heralding a new dawn of discovery and efficiency.

Biosensing in Drug Discovery

Biosensing in Drug Discovery

In life science research and drug discovery, biosensing technology is a pivotal innovation. This blog dives into the expansive potential of biosensing, particularly emphasizing the groundbreaking impact of label-free biosensing. We’ll also explore how multiplexed biosensors enable the detection of multiple interactions within the same sample, thereby transforming high-throughput screening.

What is Biosensing?

Biosensing involves detecting and measuring biological molecules via sophisticated biosensors. These devices combine biological recognition elements (like enzymes or antibodies) with transducers (like electrodes or optical systems) to convert biological interactions into quantifiable signals. Biosensing’s diverse applications range from clinical diagnostics and environmental monitoring to groundbreaking drug development.

What is Label-Free Biosensing?

Traditional biosensing methods often require labels (fluorescent or radioactive) for molecular identification. However, label-free biosensing changes the game by directly detecting biomolecular interactions, eliminating the need for labels. This approach preserves the natural behavior of biomolecules, offering more accurate insights.

Applications of Label-Free Biosensing in Drug Discovery

Label-free biosensing significantly influences life science research and drug discovery. Its primary use is in analyzing biomolecules’ binding kinetics, which is essential in selecting antibodies for therapeutic or diagnostic purposes. Label-free biosensors enable precise screening of antibodies, assessing their binding characteristics to specific targets.

Multiplexed Biosensors & High Throughput Screening

The advantage of multiplexity in high throughput screening is profound, especially in drug discovery. High throughput screening is used to conduct millions of chemical, genetic, or pharmacological tests rapidly. The goal is to identify active compounds, antibodies, or genes that modulate a particular biomolecular pathway. The traditional approach to screening involves testing one drug target or condition per experiment, which can be time-consuming and resource-intensive.

By employing multiplexed biosensors, it’s possible to have concurrent analysis of multiple samples against various targets. This saves time by reducing the number of individual tests needed and provides a more comprehensive understanding of how different compounds interact with multiple biological targets at once. This comprehensive data is invaluable for identifying potential effective drug candidates with minimal side effects.

For instance, a multiplexed biosensor could assess how a compound interacts with different cellular receptors, enzymes, and proteins in a single experiment. This holistic view can quickly highlight any adverse cross-reactivity of the compound, which is crucial for drug safety.

Delta Diagnostics Enhancing Research Capabilities

Biosensing, especially label-free biosensing, revolutionizes life science research and drug discovery. With Delta Diagnostics at the forefront, detecting more interactions in a single sample, and advancing high throughput screening, the future of healthcare and scientific exploration looks promising.

Using multiplexed biosensors in high throughput screening by Delta Diagnostics marks a significant advancement in drug discovery. By enabling the simultaneous analysis of multiple interactions, these biosensors accelerate the process of identifying potential drug candidates and enhance the depth and quality of the data collected, leading to more efficient and effective drug development pipelines.

Our DeltaOne elevates label-free biosensing with advanced technology, detecting numerous interactions simultaneously within a single sample. This capability provides richer data from individual experiments, enhancing understanding of biological processes. It also streamlines the antibody selection process, saving time and resources.

Director Business Development

Location: Rotterdam or Enschede

Job Type: Full-Time

About Us:

Delta Diagnostics is a dynamic and innovative scale up in the life sciences industry, committed to advancing healthcare through cutting-edge research, development, and commercialization. With a strong focus on innovation, collaboration, and excellence, we are dedicated to improving the quality of life for individuals around the world.

Job Description:

We are seeking a highly motivated and experienced Director of Business Development to join our team in the fast-paced and ever-evolving field of life sciences. As the Director of Business Development, you will play a pivotal role in driving our growth strategy, identifying and cultivating new business opportunities, and forging strategic partnerships that will propel our company to new heights.

Responsibilities:

1. Market Analysis: Conduct in-depth market research and analysis to identify emerging trends, competitive landscape, and potential growth areas within the life sciences industry.

2. Business Strategy: Develop and implement a comprehensive business development and go-to-market strategy aligned with the company’s goals and objectives.

3. Lead Generation: Generate and maintain a robust pipeline of potential partnerships, collaborations, and business opportunities with distributors, universities, research institutions, pharmaceutical companies, and other relevant organizations.

4. Relationship Building: Build and nurture strong relationships with key stakeholders, including potential clients, partners, and investors, to drive successful collaborations.

5. Negotiation: Lead negotiations and contract discussions, ensuring favourable terms and agreements that align with company goals and compliance requirements.

6. Team Leadership: Provide leadership and mentorship to the business development and after sales team, fostering a culture of excellence and accountability.

7. Financial Analysis: Evaluate the financial feasibility of potential deals, including revenue projections, cost-benefit analysis, and ROI assessments.

8. Strategic Planning: Collaborate with cross-functional teams to align business development efforts with research, development, and commercialization strategies.

9. Reporting and Analytics: Regularly report on business development activities and progress to senior management, leveraging data-driven insights to refine strategies.

10. Compliance: Ensure that all business development activities adhere to industry regulations and ethical standards.

Qualifications:

1. Masters degree in a relevant field; MBA or advanced degree preferred.

2. Minimum of 10-15 years of experience in business development, strategic partnerships, or related roles within the life sciences industry.

3. Proven track record of successfully bringing a product to the market, identifying and executing strategic partnerships and collaborations.

4. Strong understanding of the life sciences market, including pharmaceuticals, biotechnology, and healthcare.

5. Excellent negotiation, communication, and interpersonal skills.

6. Exceptional leadership and team management abilities.

7. Analytical mindset with proficiency in financial modelling and analysis.

8. Ability to thrive in a scale up environment that is fast-paced and results-driven.

9. Strong ethical and compliance orientation.

Why Join Us:

Joining Delta Diagnostics means becoming part of a dedicated team that is passionate about advancing healthcare and making a positive impact on people’s lives. We offer competitive compensation with a results based variable pay component, a supportive work environment, opportunities for professional growth and development and as a plus (if you stay for the duration) a generous cash bonus on exit scheme.

If you are a strategic thinker, a collaborative leader, and have a deep understanding of the life sciences industry, we encourage you to apply and contribute to our mission of innovation and excellence in healthcare.

How to Apply:

Interested candidates are invited to submit their resume and a cover letter outlining their qualifications and experience to careers@deltadiagnostics.nl.

Delta Diagnostics is an equal opportunity employer committed to diversity and inclusion in the workplace. We encourage individuals from underrepresented groups to apply.

Click or drag a file to this area to upload.
Click or drag a file to this area to upload.

Systems Engineer – Senior

Location: Rotterdam and Enschede, The Netherlands

Employment Type: 0.8 – 1 FTE

Experience: Minimum 5 years

About Delta Diagnostics:

Delta Diagnostics is a leading developer of cutting-edge life-science research instruments based on photonic integrated circuit technology that was invented at TNO – The Netherlands Organization for Applied Scientific Research. With a strong commitment to advancing scientific knowledge and vastly accelerating the development of new drugs and diagnostic tests, Delta Diagnostics is at the forefront of innovation, developing state-of-the-art label-free biosensors that empower researchers and healthcare professionals worldwide. We aim to deliver highly reliable, efficient, and user-friendly instruments that enable researchers to unravel the complexities of biological samples and accelerate scientific breakthroughs.

We are dedicated to creating instruments that not only provide accurate and precise results but also streamline workflows, saving researchers valuable time and resources. Our ultimate goal is to contribute to the improvement of global healthcare by facilitating the development of innovative diagnostic tools and accelerating the development of new drugs.

Join us at Delta Diagnostics as we embark on this exciting journey of discovery and innovation, where your expertise and passion can make a significant impact on scientific advancements and patient care. Together, let’s shape the future of life-science research and diagnostics.

Job Description:

We are seeking a talented and experienced Systems Engineer to join our rapidly growing dynamic team at Delta Diagnostics. As a Systems Engineer, you will play a key role in the development of the next generation label-free biosensing instruments that will accelerate life-science research. The ideal candidate will have a strong background in systems engineering, with a focus on the development of complex instruments used in the life sciences field, and thrives in a dynamic scale-up environment in which every individual plays a significant role in shaping the success of a company.

Responsibilities:

· Collaborate with cross-functional teams to define system requirements and specifications for life-science research instruments analyzing liquid samples or in vitro diagnostic devices.

· Manage subcontractors and suppliers involved in the development of the instruments

· Design and develop system architectures, subsystems, and components, ensuring alignment with project objectives and technical requirements.

· Conduct feasibility studies and risk assessments to identify potential issues and propose effective solutions.

· Implement and integrate software modules or microfluidic components into the overall system design.

· Conduct system testing and verification activities to ensure functionality, performance, and reliability.

· Troubleshoot and resolve technical issues during the development and testing phases.

· Generate detailed technical documentation, including system requirements, design specifications, and test protocols.

· Stay updated with target user needs, industry trends, advancements, and emerging technologies relevant to life-science research instruments and contribute to the development of our own product roadmap.

Requirements:

· Master’s or PhD degree in Engineering, Bioengineering, or a related field.

· Minimum of 5 years of professional experience in the development of life-science research instruments analyzing liquid samples or in vitro diagnostic devices.

· Strong understanding of systems engineering principles and practices.

· Proficiency in designing and integrating complex systems, including mechanical, electrical, optical, microfluidic and software components.

· Familiarity with software development methodologies and programming languages is a plus.

· Experience with microfluidic systems or related technologies would be advantageous.

· Knowledge of regulatory requirements and standards applicable to life-science research (ROU) instruments is preferred.

· Excellent problem-solving skills and ability to work effectively in multidisciplinary teams.

· Strong communication skills to collaborate with team members, stakeholders, and external partners.

We offer competitive compensation, a stimulating scale-up environment, and opportunities for professional growth and development. If you are passionate about developing innovative life-science research instruments and have the required expertise, we would love to hear from you. Please submit your resume and cover letter to info@deltadiagnostics.nl.

Delta Diagnostics is an equal opportunity employer committed to diversity and inclusion in the workplace. We encourage individuals from underrepresented groups to apply.

Click or drag a file to this area to upload.
Click or drag a file to this area to upload.